{"product_id":"presenilin-1-polyclonal-antibody-ra29002","title":"Presenilin 1 Polyclonal Antibody - RA29002","description":"Presenilin 1 Polyclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: RA29002-50, RA29002-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: presenilin 1 (PSEN1) Homo sapiens Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP) . These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains) . Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008],\n\nCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\n\nStorage Instructions: -20°C\/1 year\n\nRecommended dilutions: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/5000. Not yet tested in other applications.\n\nAlternative Names: PSEN1; AD3; PS1; PSNL1; Presenilin-1; PS-1; Protein S182\n\nApplications: WB; IHC-p; IF (paraffin section) ; ELISA\n\nSpecies Cross-Reactivity: Human; Mouse; Rat\n\nGeneID (Human): 5663\n\nProtein MW (KDa): 43\n\nSWISS: P49768\n\nSource: Rabbit\n\nResearch Use Only","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45122375057587,"sku":"RA29002-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45122375090355,"sku":"RA29002-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_c62a32f2-18f0-4a32-8ebe-a3b23e605b20.png?v=1773348151","url":"https:\/\/afsbio.com\/products\/presenilin-1-polyclonal-antibody-ra29002","provider":"AFSBio Inc.","version":"1.0","type":"link"}