{"product_id":"presenilin-2-phospho-ser330-polyclonal-antibody-ra29003","title":"Presenilin 2 (phospho Ser330) Polyclonal Antibody - RA29003","description":"Presenilin 2 (phospho Ser330) Polyclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: RA29003-50, RA29003-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: presenilin 2 (PSEN2) Homo sapiens Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP) . These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains) . Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008],\n\nCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\n\nStorage Instructions: -20°C\/1 year\n\nRecommended dilutions: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/5000. Not yet tested in other applications.\n\nAlternative Names: PSEN2; AD4; PS2; PSNL2; STM2; Presenilin-2; PS-2; AD3LP; AD5; E5-1; STM-2\n\nApplications: WB; IHC-p; IF (paraffin section) ; ELISA\n\nSpecies Cross-Reactivity: Human; Mouse; Rat\n\nGeneID (Human): 5664\n\nProtein MW (KDa): 50\n\nSWISS: P49810\n\nSource: Rabbit\n\nResearch Use Only","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45122375123123,"sku":"RA29003-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45122375155891,"sku":"RA29003-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_b5e6fbaf-77a2-4695-9aeb-a6e745e6a64d.png?v=1773348152","url":"https:\/\/afsbio.com\/products\/presenilin-2-phospho-ser330-polyclonal-antibody-ra29003","provider":"AFSBio Inc.","version":"1.0","type":"link"}