{"product_id":"presenilin-2-rabbit-polyclonal-antibody-ra29004","title":"Presenilin 2 Rabbit Polyclonal Antibody - RA29004","description":"Presenilin 2 Rabbit Polyclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: RA29004-50, RA29004-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: presenilin 2 (PSEN2) Homo sapiens Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP) . These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains) . Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008],\n\nCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\n\nStorage Instructions: -20°C\/1 year\n\nRecommended dilutions: WB 1:1000-2000 ELISA 1:5000-20000\n\nAlternative Names: Presenilin-2 (PS-2;EC 3.4.23.-;AD3LP;AD5;E5-1;STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]\n\nApplications: WB; ELISA\n\nSpecies Cross-Reactivity: Human; Mouse; Rat\n\nGeneID (Human): 5664\n\nSWISS: P49810\n\nSource: Rabbit\n\nResearch Use Only","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45120356614323,"sku":"RA29004-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45120356647091,"sku":"RA29004-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_1d7ae0a5-1227-40be-b527-4cb488bb9b9c.png?v=1773357596","url":"https:\/\/afsbio.com\/products\/presenilin-2-rabbit-polyclonal-antibody-ra29004","provider":"AFSBio Inc.","version":"1.0","type":"link"}