{"product_id":"prf1-monoclonal-antibody-bt-mca2349","title":"PRF1 Monoclonal Antibody - BT-MCA2349","description":"\u003cp\u003ePRF1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2349-50, BT-MCA2349-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Others\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PRF1\u003c\/p\u003e\n\n\u003cp\u003eApplications: FCM\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 6F8C2\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: PRF1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human PRF1 (AA: extra 148-372) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 61.3kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P14222\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: P1, PFP, HPLH2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 5551\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238388719795,"sku":"BT-MCA2349-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238388752563,"sku":"BT-MCA2349-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_b132633f-4d94-4782-8e40-0348f793a13a.png?v=1769379756","url":"https:\/\/afsbio.com\/products\/prf1-monoclonal-antibody-bt-mca2349","provider":"AFSBio Inc.","version":"1.0","type":"link"}