{"product_id":"prio-polyclonal-antibody-bt-ap13305","title":"PRIO Polyclonal Antibody - BT-AP13305","description":"\u003cp\u003ePRIO Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP13305-20, BT-AP13305-50, BT-AP13305-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Neuroscience; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PRNP\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Major prion protein\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P04156; Mouse: P04925; Rat: P13852\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Major prion protein;PrP;ASCR;PrP27-30;PrP33-35C;CD antigen CD230\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 5621\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239297736883,"sku":"BT-AP13305-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239297769651,"sku":"BT-AP13305-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239297802419,"sku":"BT-AP13305-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_ccd4b1ad-42f8-47f8-bb29-ef238d36cf95.png?v=1769392700","url":"https:\/\/afsbio.com\/products\/prio-polyclonal-antibody-bt-ap13305","provider":"AFSBio Inc.","version":"1.0","type":"link"}