{"product_id":"prk2-pkn2-polyclonal-antibody-e-ab-92026","title":"PRK2\/PKN2 Polyclonal Antibody - E-AB-92026","description":"\u003cp\u003ePRK2\/PKN2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-92026-60, E-AB-92026-120, E-AB-92026-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PRK2\/PKN2\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: PAK2; PRK2; PRKCL2; PRO2042; Pak-2; STK7; PKN2\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q16513\u003c\/p\u003e\n\n\u003cp\u003eBackground: PKC-related serine\/threonine-protein kinase and Rho\/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2\/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF. Involved in the negative regulation of ciliogenesis.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide of human PRK2\/PRK2\/PKN2\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 75kDa\/94kDa\/106kDa\/110kDa\/112kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 140kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43148832506035,"sku":"E-AB-92026-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43148832538803,"sku":"E-AB-92026-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43148832571571,"sku":"E-AB-92026-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_74e92458-9434-4474-8a44-6db332d6878c.png?v=1710330940","url":"https:\/\/afsbio.com\/products\/prk2-pkn2-polyclonal-antibody-e-ab-92026","provider":"AFSBio Inc.","version":"1.0","type":"link"}