{"product_id":"prkab2-polyclonal-antibody-e-ab-61427","title":"PRKAB2 Polyclonal Antibody - E-AB-61427","description":"\u003cp\u003ePRKAB2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-61427-60, E-AB-61427-120, E-AB-61427-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PRKAB2\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: PRKAB2\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer,Cardiovascular,Metabolism,Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IF\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: O43741\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human PRKAB2\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IF 1:50-1:100\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 21kDa\/30kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 33KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146166010035,"sku":"E-AB-61427-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146166042803,"sku":"E-AB-61427-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146166075571,"sku":"E-AB-61427-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_675c1f84-6145-476e-8025-e99645be3f24.png?v=1710291489","url":"https:\/\/afsbio.com\/products\/prkab2-polyclonal-antibody-e-ab-61427","provider":"AFSBio Inc.","version":"1.0","type":"link"}