{"product_id":"progesterone-receptor-monoclonal-antibody-mb66216","title":"Progesterone Receptor Monoclonal Antibody-MB66216","description":"\u003cp\u003eProgesterone Receptor Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66216-50, MB66216-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG1. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P06401\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: IHC (1\/100 - 1\/300)\u003c\/p\u003e\n\n\u003cp\u003eBackground: Human progesterone receptor (PR) is expressed as two forms: the full length PR-B and the short form PR-A. PR-A lacks the first 164 amino acid residues of PR-B (1,2). Both PR-A and PR-B are ligand activated, but differ in their relative ability to activate target gene transcription (3,4). The activity of PR is regulated by phosphorylation; at least seven serine residues are phosphorylated in its amino-terminal domain. Three sites (Ser81, Ser102, and Ser162) are unique to full length PR-B, while other sites (Ser190, Ser294, Ser345, and Ser400) are shared by both isoforms . Phosphorylation of PR-B at Ser190 (equivalent to Ser26 of PR-A) is catalyzed by CDK2 . Mutation of Ser190 results in decreased activity of PR , suggesting that the phosphorylation at Ser190 may be critical to its biological function.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Immunohistochemical analysis of Progesterone Receptor staining in human breast carcinoma formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6. 0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 98 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of Progesterone Receptor protein.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: NR3C3; Progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH-conjugated synthetic peptide encompassing a sequence within human Progesterone Receptor. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42939241660595,"sku":"MB66216-50","price":254.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42939241693363,"sku":"MB66216-100","price":442.75,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_f77cb98f-b2ca-4078-b94b-650d025e73cc.jpg?v=1704545479","url":"https:\/\/afsbio.com\/products\/progesterone-receptor-monoclonal-antibody-mb66216","provider":"AFSBio Inc.","version":"1.0","type":"link"}