{"product_id":"proteinase-3-monoclonal-antibody-bt-mca3445","title":"Proteinase 3 Monoclonal Antibody - BT-MCA3445","description":"\u003cp\u003eProteinase 3 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA3445-50, BT-MCA3445-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Proteinase 3, also known as PRTN3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Others\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: Proteinase 3\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 3B4\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG2b\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Proteinase 3\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human Proteinase 3 expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 28kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P24158\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: PRTN3, ACPA, CANCA\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 5657\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238427975859,"sku":"BT-MCA3445-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238428008627,"sku":"BT-MCA3445-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_2d817d88-b33d-4ac0-ac42-ec376126445f.png?v=1769380646","url":"https:\/\/afsbio.com\/products\/proteinase-3-monoclonal-antibody-bt-mca3445","provider":"AFSBio Inc.","version":"1.0","type":"link"}