{"product_id":"prp19-rabbit-monoclonal-antibody-bs40218","title":"PRP19 Rabbit Monoclonal Antibody-BS40218","description":"\u003cp\u003ePRP19 Rabbit Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS40218-50, BS40218-100\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q9UMS4\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003ePRP19 Rabbit Monoclonal Antibody-BS40218\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC ICC\/IF FC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB 1:500~1:2000 IHC 1:50~1:200 ICC\/IF 1:50~1:200 FC 1:50\u003c\/p\u003e\n\n\u003cp\u003eBackground: Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C\/Prp19 complex\/NTC\/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4\/U5\/U6 tri-snRNP spliceosomal complex (PubMed:20595234).\u003c\/p\u003e\n\n\n\n\u003cp\u003ePurification and Purity: Affinity-chromatography\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: PRP19 Antibody detects endogenous levels of PRP19\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 55kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of PRP19 expression in (1) HepG2 cell lysate; (2) NIH\/3T3 cell lysate., Immunohistochemical analysis of paraffin-embedded human cervix cancer, using PRP19 Antibody.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: NMP200; nuclear matrix protein 200; pre-mRNA-processing factor 19; PRP19; PRP19\/PSO4; PRPF19; PSO4; senescence evasion factor; SNEV; UBOX4;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: A synthesized peptide derived from human PRP19\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42957284704435,"sku":"BS40218-50","price":276.71,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42957284737203,"sku":"BS40218-100","price":490.83,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_a770764e-2b2c-4a23-86c1-5dce6148af96.jpg?v=1705144375","url":"https:\/\/afsbio.com\/products\/prp19-rabbit-monoclonal-antibody-bs40218","provider":"AFSBio Inc.","version":"1.0","type":"link"}