{"product_id":"pten-monoclonal-antibody-bt-mca4500","title":"PTEN Monoclonal Antibody - BT-MCA4500","description":"\u003cp\u003ePTEN Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4500-50, BT-MCA4500-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: PTEN (phosphatase and tensin homolog) was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. This protein is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT\/PKB signaling pathway.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PTEN\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ICC, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 1B8\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: PTEN\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of PTEN expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 54kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P60484\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: BZS, MHAM, TEP1, PTEN1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 5728\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238630482099,"sku":"BT-MCA4500-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238630514867,"sku":"BT-MCA4500-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_5ba41c2c-54f9-4594-8b7f-72a3eef3cb51.png?v=1769383229","url":"https:\/\/afsbio.com\/products\/pten-monoclonal-antibody-bt-mca4500","provider":"AFSBio Inc.","version":"1.0","type":"link"}