{"product_id":"ptpα-phospho-tyr798-rabbit-polyclonal-antibody-es6938","title":"PTPα (phospho Tyr798) Rabbit Polyclonal Antibody - ES6938","description":"\u003cp\u003ePTPα (phospho Tyr798) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES6938-50, ES6938-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat, Monkey\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA, IHC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: PTPRA, PTPA, PTPRL2, Receptor-type tyrosine-protein phosphatase alpha, Protein-tyrosine phosphatase alpha, R-PTP-alpha\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human PTPRA around the phosphorylation site of Tyr798. AA range:753-802\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: PTPα\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Phospho-PTPα (Y798) Polyclonal Antibody detects endogenous levels of PTPα protein only when phosphorylated at Y798.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Brain, Epithelium, Kidney, Lymph node, Skin,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 100 90kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate\u003cbr\u003e\nSimilarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily\u003cbr\u003e\nSimilarity: Contains 2 tyrosine-protein phosphatase domains\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Cell membrane, Single-pass type I membrane protein Cell junction, focal adhesion Localizes to focal adhesion sites following integrin engagement\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: PTPRA\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Receptor-type tyrosine-protein phosphatase alpha\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 19262\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P18052\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q03348\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313663758515,"sku":"ES6938-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313663791283,"sku":"ES6938-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/ptp%ce%b1-phospho-tyr798-rabbit-polyclonal-antibody-es6938","provider":"AFSBio Inc.","version":"1.0","type":"link"}