{"product_id":"ptp-ia-2beta-polyclonal-antibody-bt-ap07490","title":"PTP IA-2Beta Polyclonal Antibody - BT-AP07490","description":"\u003cp\u003ePTP IA-2Beta Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP07490-20, BT-AP07490-50, BT-AP07490-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: PTPRN2 (protein tyrosine phosphatase, receptor type N2) encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PTPRN2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: PTP IA-2beta Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 111271\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q92932; Mouse: P80560; Rat: Q63475\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: PTPRN2; KIAA0387; Receptor-type tyrosine-protein phosphatase N2; R-PTP-N2; Islet cell autoantigen-related protein; IAR; ICAAR; Phogrin\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 5799; Mouse: 19276; Rat: 29714\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239859216563,"sku":"BT-AP07490-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239859249331,"sku":"BT-AP07490-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239859282099,"sku":"BT-AP07490-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_df5df996-e2e8-4392-a4ee-70276579659b.png?v=1769400081","url":"https:\/\/afsbio.com\/products\/ptp-ia-2beta-polyclonal-antibody-bt-ap07490","provider":"AFSBio Inc.","version":"1.0","type":"link"}