{"product_id":"ptpn1-ptp1b-mouse-monoclonal-antibody-mb4298","title":"PTPN1 (PTP1B) Mouse Monoclonal Antibody - MB4298","description":"\u003cp\u003ePTPN1 (PTP1B) Mouse Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 25μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB4298-25, MB4298-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecμles that regμlate a variety of cellμlar processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regμlator of insμlin signaling by dephosphorylating the phosphotryosine residues of insμlin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimμlation. [provided by RefSeq]\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Dog, Monkey, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: FC, IF, IHC, WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: PTP1B\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Fμll length human recombinant protein of human PTPN1(NP_002818) produced in HEK293 cell.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500~2000, IHC 1:150, IF 1:100, FLOW 1:100\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from mouse ascites fluids or tissue cμlture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IgG2a\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: 49.8 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P18031\u003c\/p\u003e\n\n\u003cp\u003eProduct: 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"25μl","offer_id":45945977700531,"sku":"MB4298-25","price":289.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45945977733299,"sku":"MB4298-100","price":642.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/ptpn1-ptp1b-mouse-monoclonal-antibody-mb4298","provider":"AFSBio Inc.","version":"1.0","type":"link"}