{"product_id":"ptpn11-monoclonal-antibody-bt-mca2963","title":"PTPN11 Monoclonal Antibody - BT-MCA2963","description":"\u003cp\u003ePTPN11 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2963-50, BT-MCA2963-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PTPN11\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC, ICC, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 6D9\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: PTPN11\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human PTPN11 (AA: 263-329) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 68.4kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q06124\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: CFC, NS1, SHP2, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP3, MGC14433\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 5781\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238571335859,"sku":"BT-MCA2963-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238571368627,"sku":"BT-MCA2963-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_181a18f0-25af-45cc-a9c0-5fa560ac9205.png?v=1769382692","url":"https:\/\/afsbio.com\/products\/ptpn11-monoclonal-antibody-bt-mca2963","provider":"AFSBio Inc.","version":"1.0","type":"link"}