{"product_id":"ptprf-monoclonal-antibody-bt-mca4302","title":"PTPRF Monoclonal Antibody - BT-MCA4302","description":"\u003cp\u003ePTPRF Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4302-50, BT-MCA4302-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Neuroscience, Signal transduction, Metabolism\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PTPRF\u003c\/p\u003e\n\n\u003cp\u003eApplications: FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 6D7C7\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: PTPRF\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human PTPRF (AA: extra 1104-1163) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 213kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P10586\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: LAR, BNAH2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 5792\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238538633395,"sku":"BT-MCA4302-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238538666163,"sku":"BT-MCA4302-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_ade4e99a-676a-4a83-9411-087359f4fc7a.png?v=1769382355","url":"https:\/\/afsbio.com\/products\/ptprf-monoclonal-antibody-bt-mca4302","provider":"AFSBio Inc.","version":"1.0","type":"link"}