{"product_id":"ptprk-rabbit-polyclonal-antibody-es10142","title":"PTPRK Rabbit Polyclonal Antibody - ES10142","description":"\u003cp\u003ePTPRK Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES10142-50, ES10142-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: approximately 7-10 business days, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008],\u003c\/p\u003e \n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human protein . at AA range: 180-260\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: PTPRK,\u003c\/p\u003e \n\n\u003cp\u003eSpecificity: PTPRK Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e \n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 158kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Forms complexes with beta-catenin and gamma-catenin\/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTP-kappa. PTM: This protein undergoes proteolytic processing. Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Similarity: Contains 1 MAM domain. Similarity: Contains 2 tyrosine-protein phosphatase domains. Similarity: Contains 4 fibronectin type-III domains. Tissue Specificity: High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.\u003c\/p\u003e \n\n\u003cp\u003eSubcellular Location: Cell junction, adherens junction. Cell membrane, Single-pass type I membrane protein.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: PTPRK, PTPK\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Receptor-type tyrosine-protein phosphatase kappa, Protein-tyrosine phosphatase kappa, R-PTP-kappa, EC 3.1.3.48\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 5796\u003c\/p\u003e\n\n\u003cp\u003eHuman SwissProt Number: Q15262\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P35822\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":45825496187059,"sku":"ES10142-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45825496219827,"sku":"ES10142-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk-biotechnology-logo-product.jpg?v=1786476023","url":"https:\/\/afsbio.com\/products\/ptprk-rabbit-polyclonal-antibody-es10142","provider":"AFSBio Inc.","version":"1.0","type":"link"}