{"product_id":"ptprn-polyclonal-antibody-e-ab-52202","title":"PTPRN Polyclonal Antibody - E-AB-52202","description":"\u003cp\u003ePTPRN Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-52202-60, E-AB-52202-120, E-AB-52202-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PTPRN\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: CA 512; FLJ16131; IA 2; IA 2\/PTP; IA2; IA2\/PTP; ICA 3; ICA 512; ICA3; ICA512; Islet cell antigen 2; Islet cell antigen 512; Islet cell autoantigen 3; Protein tyrosine phosphatase like N; Protein tyrosine phosphatase like N precursor; Protein tyrosine phosphatase receptor type N; PTP IA 2; PTP IA-2; PTP IA2; PTPIA 2; PTPN; Ptprn; PTPRN protein; PTPRN; R PTP N; R-PTP-N; Receptor type tyrosine protein phosphatase like N; Receptor-type tyrosine-protein phosphatase-like N; RPTPN\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Metabolism, Neuroscience, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q16849\u003c\/p\u003e\n\n\u003cp\u003eBackground: IA-2\/PTPRN is a member of the protein tyrosine phosphatase (PTP) family, which contains a transmembrane region, an intracellular PTP-like domain and an extracellular N-terminus. Experiments found that IA-2\/PTPRN localizes to secretory granules and is exclusively expressed in neuroendocrine cells (including pancreatic islets cell). IA-2\/PTPRNwas found to be a major autoantigen in insulin-dependent diabetes mellitus and the detection of autoantibodies against IA-2\/PTPRN is commonly used as a diabetes diagnosis marker.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.96 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Fusion protein of human PTPRN\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:50-1:200, ELISA 1:5000-1:10000\u003c\/p\u003e\n\n \n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43133457170611,"sku":"E-AB-52202-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43133457203379,"sku":"E-AB-52202-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43133457236147,"sku":"E-AB-52202-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_b7925a9f-ac2c-44aa-a32d-c855c443c8a4.png?v=1709899243","url":"https:\/\/afsbio.com\/products\/ptprn-polyclonal-antibody-e-ab-52202","provider":"AFSBio Inc.","version":"1.0","type":"link"}