{"product_id":"puma-polyclonal-antibody-ra21437","title":"PUMA Polyclonal Antibody - RA21437","description":"\u003cp\u003ePUMA Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA21437-50, RA21437-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: BCL2 binding component 3 (BBC3) Homo sapiens This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: BBC3; PUMA; Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 27113\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 23\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q9BXH1\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121066139827,"sku":"RA21437-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121066172595,"sku":"RA21437-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_0b96c48d-6c73-44df-97cd-1f952ef8ccc0.png?v=1773370335","url":"https:\/\/afsbio.com\/products\/puma-polyclonal-antibody-ra21437","provider":"AFSBio Inc.","version":"1.0","type":"link"}