{"product_id":"puma-rabbit-pab-es3285","title":"PUMA rabbit pAb - ES3285","description":"\u003cp\u003ePUMA rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES3285-50, ES3285-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: BBC3; PUMA; Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human PUMA. AA range:120-169\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 23kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 27113\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q9BXH1\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Mitochondrion. Localized to the mitochondria in order to induce cytochrome c release.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202125684915,"sku":"ES3285-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202125717683,"sku":"ES3285-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_421aa300-9fdc-4ed8-9c57-9fcf2a9c959f.png?v=1767122519","url":"https:\/\/afsbio.com\/products\/puma-rabbit-pab-es3285","provider":"AFSBio Inc.","version":"1.0","type":"link"}