{"product_id":"qsk-polyclonal-antibody-bs62472","title":"QSK Polyclonal Antibody-BS62472","description":"\u003cp\u003eQSK Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS62472-50, BS62472-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q9Y2K2\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB  IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:500~1:1000  IHC:1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine\/ threonine (Ser\/Thr) protein kinases. The salt-inducible kinases (SIKs) are a family of related serine-threonine kinases and are key enzymes that modulate important processes such as steroid hormone biosynthesis and Insulin signaling in adipocytes. QSK, also known as L19 or SIK3 (salt-inducible kinase 3), is a 1,263 amino acid cytoplasmic protein belonging to the protein kinase superfamily, CAMK Ser\/Thr protein kinase family and the AMPK subfamily. Ubiquitously expressed, QSK consists of one protein kinase domain and a UBA domain. QSK is activated by 14-3-3 ζ and utilizes magnesium as a cofactor. QSK exists as three alternatively spliced isoforms.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The protein was purified from E.coli and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: QSK polyclonal antibody detects endogenous levels of QSK protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of QSK polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLaneA:L02 whole cell lysate\u003cbr\u003e\nLaneB:MCF-7 whole cell lysate\u003cbr\u003e\nLaneC:A549 whole cell lysate\u003cbr\u003e\nLaneD:CT-26 whole cell lysate\u003cbr\u003e\nLaneE:PC12 whole cell lysate\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 140 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Serine\/threonine-protein kinase SIK3; Salt-inducible kinase 3; SIK-3; Serine\/threonine-protein kinase QSK; SIK3; KIAA0999; QSK; L19\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to Human QSK.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42910461100211,"sku":"BS62472-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42910461132979,"sku":"BS62472-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_7953c416-9f2f-4e07-8e8b-ec91431664be.jpg?v=1703092855","url":"https:\/\/afsbio.com\/products\/qsk-polyclonal-antibody-bs62472","provider":"AFSBio Inc.","version":"1.0","type":"link"}