{"product_id":"r-spondin1-monoclonal-antibody-bt-mca4135","title":"R-spondin1 Monoclonal Antibody - BT-MCA4135","description":"\u003cp\u003eR-spondin1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4135-50, BT-MCA4135-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP_001033722.1. It is a member of the R-spondin family and a 28.9kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt\/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled\/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Others\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: R-spondin1\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 7A6\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: R-spondin1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of R-spondin1 expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 28.9kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q2MKA7\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: RSPO1, CRISTIN3, FLJ40906\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 284654\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238428598451,"sku":"BT-MCA4135-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238428631219,"sku":"BT-MCA4135-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_2fe68658-55c1-402b-9ad2-54420cea2238.png?v=1769380663","url":"https:\/\/afsbio.com\/products\/r-spondin1-monoclonal-antibody-bt-mca4135","provider":"AFSBio Inc.","version":"1.0","type":"link"}