{"product_id":"rab-5a-rabbit-pab-es4186","title":"Rab 5A rabbit pAb - ES4186","description":"\u003cp\u003eRab 5A rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES4186-50, ES4186-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: enzyme regulation:Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP., function:Required for the fusion of plasma membranes and early endosomes., similarity:Belongs to the small GTPase superfamily. Rab family., subcellular location:Enriched in stage I melanosomes., subunit:Binds EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with ALS2CL, UNC84B, ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: RAB5A; RAB5; Ras-related protein Rab-5A\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. IHC-p: 1\/100-1\/300. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human RAB5A. AA range:71-120\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 24kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 5868\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P20339\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome. Cytoplasmic vesicle. Cell projection, ruffle. Membrane. Cytoplasm, cytosol. Cytoplasmic vesicle, phagosome membrane. Endosome membrane. Enriched in stage I melanosomes (PubMed:17081065). Alternates between membrane-bound and cytosolic forms (Probable).\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202181324979,"sku":"ES4186-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202181357747,"sku":"ES4186-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_981699cc-a651-42a2-bda9-fa433db2ea8a.png?v=1767123733","url":"https:\/\/afsbio.com\/products\/rab-5a-rabbit-pab-es4186","provider":"AFSBio Inc.","version":"1.0","type":"link"}