{"product_id":"rab27-monoclonal-antibody-mb67010","title":"RAB27 Monoclonal Antibody-MB67010","description":"\u003cp\u003eRAB27 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB67010-50, MB67010-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P51159\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, FC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB (1\/500 - 1\/1000), FC (1\/10 - 1\/50)\u003c\/p\u003e\n\n\u003cp\u003eBackground: Rab27 is a member of the Ras superfamily of small Rab GTPases implicated in exocytosis . The protein is localized in secretory lysosomes, such as melanosomes in melanocyte or lytic granules in cytotoxic T cells to control exosome secretion pathway. Rab27 has two isoforms, Rab27a and Rab27b. Rab27a colocalizes with part of CD63 staining vesicles, and Rab27b shows perinuclear distribution. Target knock out studies indicate that the isoforms control different steps of the exosome secretion pathway . Rab27a interacts with a wide range of effectors and is involved in multiple steps of exocytosis depending on the effector it associated with and the cell type that is involved . Rab27a has been shown to be an important player in leukocyte function, cancer metastasis and invasion, and insulin secretion.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: This antibody is purified through a protein G column.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of RAB27 protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of RAB27 expression in K562 (A) whole cell lysates.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 27 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: RAB27; Ras-related protein Rab-27A; Rab-27; GTP-binding protein Ram\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human RAB27. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42906403373235,"sku":"MB67010-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42906403406003,"sku":"MB67010-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_3fdb7868-83e7-4f7c-850a-21ac9289dae6.jpg?v=1702919077","url":"https:\/\/afsbio.com\/products\/rab27-monoclonal-antibody-mb67010","provider":"AFSBio Inc.","version":"1.0","type":"link"}