{"product_id":"rabbit-polyclonal-antibody-to-human-cdnf-300-100","title":"Rabbit Polyclonal Antibody to Human CDNF - 300-100","description":"\u003cp\u003eRabbit Polyclonal Antibody to Human CDNF\u003c\/p\u003e\n\n\u003cp\u003eSize: 100 µg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: 300-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Human CDNF\u003c\/p\u003e\n\n\u003cp\u003eImmunogen Description: Recombinant human CDNF protein produced using CHO-based Icosagen Cell factory Ltd. proprietary suspension cell line. Purified from cell culture supernatant.\u003c\/p\u003e\n\n\u003cp\u003eBackground: CDNF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- (Lindholm et al. 20007; Voutilainen et al., 2011) and MPTP-induced degeneration (Airavaara et al., 2012) of dopamine neurons in rodent models of Parkinson’s disease. When administered after 6-OHDA or MPTP –lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta\u003c\/p\u003e\n\n\u003cp\u003eUniProt ID: Q49AH0\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: ARMETL1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Rabbit polyclonal\u003c\/p\u003e\n\n\u003cp\u003eClass: IgG\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, mouse; others not tested\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA, WB, IF, IHC-P\u003c\/p\u003e\n\n\u003cp\u003eProtocol: ELISA 0.1 to 0.2 µg\/ml; WB 0.1 to 0.2 µg\/ml;  IF 0.3 to 2 µg\/ml\u003cbr\u003e\nIHC-P (on formalin-fixed, paraffin-embedded tissues, antigen retrieval) - 5 to 10 µg\/ml;\u003cbr\u003e\nMonoclonal antibody working dilution has to be established practically for each particular antigen and assay format\u003c\/p\u003e\n\n\u003cp\u003ePurification: CDNF-affinity purification\u003c\/p\u003e\n\n\u003cp\u003eBuffer: 50% saturated ammonium sulphate in PBS pH 7.4\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is shipped in non-frozen liquid form in ambient conditions\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at +4°C upon receipt. As product is (NH4)2SO4 precipitate, mix well by pipetting or vortexing prior use\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Icosagen","offers":[{"title":"Default Title","offer_id":44502416949427,"sku":"300-100","price":1195.35,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Icosagen_9227cfc5-23ed-4a1c-9c3f-742c95f4c1fe.png?v=1741969743","url":"https:\/\/afsbio.com\/products\/rabbit-polyclonal-antibody-to-human-cdnf-300-100","provider":"AFSBio Inc.","version":"1.0","type":"link"}