{"product_id":"rabbit-polyclonal-antibody-to-human-manf-mesencephalic-astrocyte-derived-neurotrophic-factor-310-100","title":"Rabbit Polyclonal Antibody to Human MANF\n (Mesencephalic Astrocyte-Derived Neurotrophic Factor) - 310-100","description":"\u003cp\u003eRabbit Polyclonal Antibody to Human MANF\u003cbr\u003e\n (Mesencephalic Astrocyte-Derived Neurotrophic Factor)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100 µg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: 310-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Human MANF\u003c\/p\u003e\n\n\u003cp\u003eImmunogen Description: Recombinant human MANF protein produced using CHO-based Icosagen Cell factory Ltd. proprietary suspension cell line. Immunogen is purified from cell culture supernatant\u003c\/p\u003e\n\n\u003cp\u003eBackground: MANF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- induced degeneration of dopamine neurons in rodent models of Parkinson’s disease (Lindholm et al., 2008, Voutilainen et al., 2009). When administered after 6-OHDA-lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta\u003c\/p\u003e\n\n\u003cp\u003eUniProt ID: P55145\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: ARMET, ARP\u003c\/p\u003e\n\n\u003cp\u003eClonality: Rabbit polyclonal\u003c\/p\u003e\n\n\u003cp\u003eClass: IgG\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human MANF\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA, WB, IF, IHC\u003c\/p\u003e\n\n\u003cp\u003eProtocol: ELISA 0.1 to 0.2 µg\/ml; WB 0.15 to 0.5 µg\/ml, IHC 10 µg\/ml, IF 1 to 20 µg\/ml\u003cbr\u003e\nNo cross-reactivity in MANF-knockout mouse. No cross-reactivity with CDNF in IHC, slightly cross-reacts with purified CDNF in WB. \u003cbr\u003e\nPolyclonal antibody working titer has to be established practically for each particular antigen and assay format\u003c\/p\u003e\n\n\u003cp\u003ePurification: MANF-affinity purified\u003c\/p\u003e\n\n\u003cp\u003eBuffer: Concentrated ammonium sulphate in PBS pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is shipped in non-frozen liquid form in ambient conditions\u003c\/p\u003e\n\n\u003cp\u003eStorage: Storage: Store at +4°C upon receipt. As product is (NH4)2SO4 precipitate, mix well by pipetting or vortexing prior use\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Icosagen","offers":[{"title":"Default Title","offer_id":44502417014963,"sku":"310-100","price":1195.35,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Icosagen_31a55ac8-6e6c-4942-941a-217912a5c948.png?v=1741969746","url":"https:\/\/afsbio.com\/products\/rabbit-polyclonal-antibody-to-human-manf-mesencephalic-astrocyte-derived-neurotrophic-factor-310-100","provider":"AFSBio Inc.","version":"1.0","type":"link"}