{"product_id":"rad17-phospho-ser635-rabbit-polyclonal-antibody-ra29190","title":"Rad17 (phospho-Ser635) Rabbit Polyclonal Antibody - RA29190","description":"\u003cp\u003eRad17 (phospho-Ser635) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA29190-50, RA29190-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: RAD17 checkpoint clamp loader component (RAD17) Homo sapiens The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, h\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: WB 1:1000-2000\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: Cell cycle checkpoint protein RAD17 (hRad17) (RF-C\/activator 1 homolog)\u003c\/p\u003e \n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Rat; Mouse\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 5884\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 77\u003c\/p\u003e\n\n\u003cp\u003eSWISS: O75943\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45122383052979,"sku":"RA29190-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45122383085747,"sku":"RA29190-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_4fceccdd-265c-4080-8e6d-8f08f17535a3.png?v=1773348236","url":"https:\/\/afsbio.com\/products\/rad17-phospho-ser635-rabbit-polyclonal-antibody-ra29190","provider":"AFSBio Inc.","version":"1.0","type":"link"}