{"product_id":"rad17-phospho-ser645-rabbit-pab-es1425","title":"Rad17 (phospho Ser645) rabbit pAb - ES1425","description":"\u003cp\u003eRad17 (phospho Ser645) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES1425-50, ES1425-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, h\u003c\/p\u003e\n\n\u003cp\u003eAlternate Name: RAD17; R24L; Cell cycle checkpoint protein RAD17; hRad17; RF-C\/activator 1 homolog\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA; IHC\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human RAD17 around the phosphorylation site of Ser645. AA range:621-670\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 77kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 5884\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: O75943\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus. Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202013520051,"sku":"ES1425-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202013552819,"sku":"ES1425-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_ce5d685f-bb8f-4ccc-8ea1-21b66dbc25e9.png?v=1767119937","url":"https:\/\/afsbio.com\/products\/rad17-phospho-ser645-rabbit-pab-es1425","provider":"AFSBio Inc.","version":"1.0","type":"link"}