{"product_id":"rad50-phospho-ser635-rabbit-pab-es13473","title":"Rad50 (phospho-Ser635) rabbit pAb - ES13473","description":"\u003cp\u003eRad50 (phospho-Ser635) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES13473-50, ES13473-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: RAD50 double strand break repair protein (RAD50) Homo sapiens The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-)\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000; IHC-p 1:50-300\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat; Mouse;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Synthesized phosho peptide around human Rad50 (Ser635)\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 153kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 10111\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q92878\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus. Chromosome, telomere. Chromosome. Localizes to discrete nuclear foci after treatment with genotoxic agents.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202404671667,"sku":"ES13473-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202404704435,"sku":"ES13473-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_e561f0ba-f338-40f6-b3ca-2962ef154837.png?v=1767128452","url":"https:\/\/afsbio.com\/products\/rad50-phospho-ser635-rabbit-pab-es13473","provider":"AFSBio Inc.","version":"1.0","type":"link"}