{"product_id":"rad50-phospho-ser635-rabbit-polyclonal-antibody-bt-ap04379","title":"Rad50 (Phospho-Ser635) Rabbit Polyclonal Antibody - BT-AP04379","description":"\u003cp\u003eRad50 (Phospho-Ser635) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP04379-20, BT-AP04379-50, BT-AP04379-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50| a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein| cooperating with its partners| is important for DNA double-strand break repair| cell cycle checkpoint activation| telomere maintenance| and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: RAD50\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Rad50\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q92878; Mouse: P70388; Rat: Q9JIL8\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Rad50;Ser635; DNA repair protein RAD50; hRAD50; EC 3.6.-.-\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 10111; Rat: 64012\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239017472179,"sku":"BT-AP04379-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239017504947,"sku":"BT-AP04379-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239017537715,"sku":"BT-AP04379-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_7950c519-2575-4e48-86b4-7b3682abd23d.png?v=1769387986","url":"https:\/\/afsbio.com\/products\/rad50-phospho-ser635-rabbit-polyclonal-antibody-bt-ap04379","provider":"AFSBio Inc.","version":"1.0","type":"link"}