{"product_id":"rai3-rabbit-polyclonal-antibody-es7943","title":"RAI3 Rabbit Polyclonal Antibody - ES7943","description":"\u003cp\u003eRAI3 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES7943-50, ES7943-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: GPRC5A, GPCR5A, RAI3, RAIG1, Retinoic acid-induced protein 3, G-protein coupled receptor family C group 5 member A, Orphan G-protein-coupling receptor PEIG-1, Retinoic acid-induced gene 1 protein, RAIG-1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human GPRC5A. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: RAI3\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: RAI3 Polyclonal Antibody detects endogenous levels of RAI3 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/10000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Expressed at high level in fetal and adult lung tissues but repressed in most human lung cancers (PubMed:9857033, PubMed:18000218), Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal cord at low to moderate levels, Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes, According to PubMed:10783259, expressed at low but detectable level in pancreas and heart,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 40kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Unknown. This G-protein coupled receptor could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. The comparable expression level in fetal lung and kidney with adult tissues suggests a possible role in embryonic development and maturation of these organs. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways\u003cbr\u003e\nInduction: By all-trans retinoic acid (ATRA)\u003cbr\u003e\nSimilarity: Belongs to the G-protein coupled receptor 3 family\u003cbr\u003e\nSubcellular Location: Localized in the plasma membrane and perinuclear vesicles\u003cbr\u003e\nTissue Specificity: Expressed at high level in fetal and adult lung tissues. Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to moderate levels. Not detectable in fetal heart,\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cell membrane, Multi-pass membrane protein Cytoplasmic vesicle membrane, Multi-pass membrane protein Localized in perinuclear vesicles, probably Golgi-associated vesicles\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: GPRC5A\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Retinoic acid-induced protein 3\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q8BHL4\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313775235251,"sku":"ES7943-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313775268019,"sku":"ES7943-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/rai3-rabbit-polyclonal-antibody-es7943","provider":"AFSBio Inc.","version":"1.0","type":"link"}