{"product_id":"ramp3-rabbit-polyclonal-antibody-es11934","title":"RAMP3 Rabbit Polyclonal Antibody - ES11934","description":"\u003cp\u003eRAMP3 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES11934-50, ES11934-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse,\u003c\/p\u003e \n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from part region of human protein\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: RAMP3\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: RAMP3 Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Strongly expressed in lung, breast, immune system and fetal tissues,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 16kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Vascular smooth muscle contraction\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL\u003cbr\u003e\nSimilarity: Belongs to the RAMP family\u003cbr\u003e\nSubunit: Heterodimer of CALCRL and RAMP3\u003cbr\u003e\nTissue Specificity: Strongly expressed in lung, breast, immune system and fetal tissues\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Cell membrane, Single-pass type I membrane protein Membrane, Single-pass type I membrane protein Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: RAMP3\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Receptor activity-modifying protein 3 (Calcitonin-receptor-like receptor activity-modifying protein 3) (CRLR activity-modifying protein 3)\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q9WUP1\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q9JJ73\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314535846067,"sku":"ES11934-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314535878835,"sku":"ES11934-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/ramp3-rabbit-polyclonal-antibody-es11934","provider":"AFSBio Inc.","version":"1.0","type":"link"}