{"product_id":"raptor-rabbit-monoclonal-antibody-bs40185","title":"Raptor Rabbit Monoclonal Antibody - BS40185","description":"\u003cp\u003eRaptor Rabbit Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS40185-50, BS40185-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The regμlatory associated protein of mTOR (Raptor) was identified as an mTOR binding partner that mediates mTOR signaling to downstream targets. Raptor binds to mTOR substrates, including 4E-BP1 and p70 S6 kinase, through their TOR signaling (TOS) motifs and is required for mTOR-mediated phosphorylation of these substrates. Binding of the FKBP12-rapamycin complex to mTOR inhibits the mTOR-raptor interaction, suggesting a mechanism for rapamycin's specific inhibition of mTOR signaling. This mTOR-raptor interaction and its regμlation by nutrients and\/or rapamycin is dependent on a protein called GβL.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human Mouse Rat\u003c\/p\u003e \n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, ICC\/IF, IP, FC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: RPTOR, KOG1, KIAA1303, RAPTOR, Mip1,\u003c\/p\u003e \n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthesized peptide derived from human Raptor\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500~1:1000 IHC 1:50~1:100 ICC\/IF 1:50~1:100 IP 1:30 FC 1:30\u003c\/p\u003e\n\n\u003cp\u003ePurification: Affinity-chromatography\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Raptor Antibody detects endogenous levels of Raptor\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: 149kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: Q8N122\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45936883794099,"sku":"BS40185-50","price":289.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45936883826867,"sku":"BS40185-100","price":492.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image.jpg?v=1788296056","url":"https:\/\/afsbio.com\/products\/raptor-rabbit-monoclonal-antibody-bs40185","provider":"AFSBio Inc.","version":"1.0","type":"link"}