{"product_id":"rb-acetyl-k873-k874-rabbit-pab-es8829","title":"Rb (Acetyl-K873\/K874) rabbit pAb - ES8829","description":"\u003cp\u003eRb (Acetyl-K873\/K874) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES8829-50, ES8829-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: Retinoblastoma-associated protein (p105-Rb) (pRb) (Rb) (pp110)\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000; IHC-p 1:50-300\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized Acetyl peptide derived from human Rb. at AA range: K873\/872\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 5925\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P06400\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus. During keratinocyte differentiation, acetylation by KAT2B\/PCAF is required for nuclear localization.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45201955782835,"sku":"ES8829-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45201955815603,"sku":"ES8829-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_acd7fd9f-845b-4178-acad-6d341e1a910a.png?v=1767118828","url":"https:\/\/afsbio.com\/products\/rb-acetyl-k873-k874-rabbit-pab-es8829","provider":"AFSBio Inc.","version":"1.0","type":"link"}