{"product_id":"rb-phospho-ser807-811-rabbit-polyclonal-antibody-bt-ap12238","title":"Rb (Phospho-Ser807\/811) Rabbit Polyclonal Antibody - BT-AP12238","description":"\u003cp\u003eRb (Phospho-Ser807\/811) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP12238-20, BT-AP12238-50, BT-AP12238-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active| hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB)| bladder cancer| and osteogenic sarcoma.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cancer; Cell biology; Epigenetics and nuclear signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: RB1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Rb\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P06400; Mouse: P13405; Rat: P33568\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Rb;Ser807\/811; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 5925; Mouse: 19645; Rat: 24708\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239017865395,"sku":"BT-AP12238-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239017898163,"sku":"BT-AP12238-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239017930931,"sku":"BT-AP12238-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_63bc8f02-ef16-4564-a8c5-d0d87b135e14.png?v=1769387991","url":"https:\/\/afsbio.com\/products\/rb-phospho-ser807-811-rabbit-polyclonal-antibody-bt-ap12238","provider":"AFSBio Inc.","version":"1.0","type":"link"}