{"product_id":"rb27a-rabbit-polyclonal-antibody-es10119","title":"RB27A Rabbit Polyclonal Antibody - ES10119","description":"\u003cp\u003eRB27A Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES10119-50, ES10119-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human protein. at AA range: 90-170\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: RB27A\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: RB27A Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Found in all the examined tissues except in brain, Low expression was found in thymus, kidney, muscle and placenta, Detected in melanocytes, and in most tumor cell lines examined, Expressed in cytotoxic T-lymphocytes (CTL) and mast cells,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 24kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Disease: Defects in RAB27A are a cause of Griscelli syndrome type-2 (GS2) [MIM: 607624]. Griscelli syndrome is a rare autosomal recessive disorder that results in pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes. GS2 patients also develop an uncontrolled T-lymphocyte and macrophage activation syndrome, known as hemophagocytic syndrome, leading to death in the absence of bone marrow transplantation. Neurological impairment is present in some patients, likely as a result of hemophagocytic syndrome\u003cbr\u003e\nOnline Information: RAB27A mutation db,Online Information: Retina International's Scientific Newsletter,Similarity: Belongs to the small GTPase superfamily. Rab family\u003cbr\u003e\nSubcellular Location: Identified by mass spectrometry in melanosome fractions from stage I to stage IV\u003cbr\u003e\nSubunit: Binds SYTL1, SYTL2, SLAC\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Membrane, Lipid-anchor Melanosome Late endosome Lysosome Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065) Localizes to endosomal exocytic vesicles (PubMed:17237785)\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: RAB27A RAB27\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Ras-related protein Rab-27A (Rab-27) (GTP-binding protein Ram)\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q9ERI2\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: P23640\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314251354291,"sku":"ES10119-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314251387059,"sku":"ES10119-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/rb27a-rabbit-polyclonal-antibody-es10119","provider":"AFSBio Inc.","version":"1.0","type":"link"}