{"product_id":"rb3-polyclonal-antibody-bt-ap07697","title":"RB3 Polyclonal Antibody - BT-AP07697","description":"\u003cp\u003eRB3 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP07697-20, BT-AP07697-50, BT-AP07697-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: RB3 (Stathmin-4), encoded by STMN4 gene, is a neuron-specific homologue of the SCG10\/stathmin family proteins, possessing a unique N-terminal membrane-associated domain and the stathmin-like domain at the C terminus, which promotes microtubule (MT) catastrophe and\/or tubulin sequestering. Stathmin is a ubiquitous cytosolic phosphoprotein, preferentially expressed in the nervous system, and described as a relay integrating diverse intracellular signaling pathways. RB3 is consistently up-regulated in differentiated neuroblastoma cells, and stable expression of transfected RB3 could induce differentiation, suggesting a role of RB3 during neuroblastoma differentiation. Moreover, increased RB3 is a unique response protein in the stathmin-related proteins following optical nerve axotomy and RB3 may be a critical target for neurodegenerative diseases.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Others\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: STMN4\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: RB3 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 22071\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9H169; Mouse: P63042; Rat: P63043\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: STMN4; Stathmin-4; Stathmin-like protein B3; RB3\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 81551; Mouse: 56471; Rat: 79423\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239874846899,"sku":"BT-AP07697-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239874879667,"sku":"BT-AP07697-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239874912435,"sku":"BT-AP07697-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_0f81b91d-83d9-4c7c-a1ce-e35fdcada0e8.png?v=1769400275","url":"https:\/\/afsbio.com\/products\/rb3-polyclonal-antibody-bt-ap07697","provider":"AFSBio Inc.","version":"1.0","type":"link"}