{"product_id":"rbap48-polyclonal-antibody-bs91160","title":"RbAP48 Polyclonal Antibody-BS91160","description":"\u003cp\u003eRbAP48 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS91160-50, BS91160-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q09028(Human) Q60972(Mouse)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ICC IHC FC IP,\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB:1:500-1:2,000\u003cbr\u003e\nICC:1:50-1:200\u003cbr\u003e\nIHC:1:50-1:200\u003cbr\u003e\nFC:1:50-1:100\u003cbr\u003e\nIP:1:10-1:50\u003c\/p\u003e\n\n\u003cp\u003eBackground: In the intact cell, DNA is closely associated with histones and other nuclear proteins to form chromatin.The remodeling of chromatin is believed to be a critical component of transcriptional regulation, and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation, and an increased accessiblity of DNA to transcription factors. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3, all of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases. The retinoblastoma binding proteins RbAp46 and RbAp48 have been identified as histone binding proteins, and they are components of the histone deacetylase complex.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: RbAP48 polyclonal antibody detects endogenous levels of RbAP48 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 48 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of RbAP48 on different lysates using anti-RbAP48 antibody at 1\/500 dilution.\u003cbr\u003e\n Positive control:\u003cbr\u003e\n Lane 1: NIH-3T3 \u003cbr\u003e\n Lane 2: Hela\u003cbr\u003e\n Lane 3: Rat brain \u003cbr\u003e\n Lane 4: Mouse testis, ICC staining RbAP48 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100\/PBS.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: CAF-1 subunit C, CAF-I 48 kDa subunit, CAF-I p48, RBBP-4, RBBP4, RBAP48, CAF I p48, CAF-1 subunit C, CAF-I 48 kDa subunit, CAF-I p48, Chromatin assembly factor 1 subunit C, Chromatin assembly factor I p48 subunit, Chromatin assembly factor\/CAF 1 p48 subunit, Histone-binding protein RBBP4, MSI1 protein homolog, Nucleosome-remodeling factor subunit RBAP48, NURF55, RB binding protein 4 chromatin remodeling factor, RbAp 48, RBAP48, RBBP-4, RBBP4, RBBP4, Retinoblastoma binding protein 4, Retinoblastoma binding protein p48, Retinoblastoma-binding protein 4, Retinoblastoma-binding protein p48,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Recombinant protein\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42984619475123,"sku":"BS91160-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42984619507891,"sku":"BS91160-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_84995af2-3f7c-4637-9997-7f92512a18b1.jpg?v=1705919484","url":"https:\/\/afsbio.com\/products\/rbap48-polyclonal-antibody-bs91160","provider":"AFSBio Inc.","version":"1.0","type":"link"}