{"product_id":"rbbp6-polyclonal-antibody-bs8619","title":"RBBP6 Polyclonal Antibody-BS8619","description":"\u003cp\u003eRBBP6 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS8619-50, BS8619-100\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q7Z6E9\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eRBBP6 Polyclonal Antibody-BS8619\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: IF\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: IF\t1:50 - 1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Rb protein and p53 are both cell cycle checkpoint components. Evidence suggests that p53 plays a role in regulating the phosphorylation of Rb by inducing p21 transcription, thus preventing Rb phosphorylation at the G1 to S transition. Protein-protein interactions seem to be central in p53 cellular activities, as previously demonstrated with MDM2 and SV40 large T antigen. Two novel proteins have been identified by their abilities to bind to p53 and\/ or Rb. Human RBQ-1 (also designated RBBP6) has been cloned as a novel protein that binds to the retinoblastoma (Rb) gene product. A related mouse protein, P2P-R, also designated PACT (for p53 associated cellular protein-testis derived), has been shown to bind to both Rb and p53. Recombinant P2P-R binds to wildtype p53 but not to mutant p53, and it can interfere with p53 specific DNA binding. RBQ-1 may be a truncated human form of the P2P-R protein.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: RBBP6 polyclonal antibody detects endogenous levels of RBBP6 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 160kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of extracts of various cell lines, using RBBP6 antibody., Immunofluorescence analysis of MCF7 cell using RBBP6 antibody. Blue: DAPI for nuclear staining.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: E3 ubiquitin-protein ligase RBBP6; EC=6.3.2.-; Proliferation potential-related protein; Protein P2P-R; Retinoblastoma-binding Q protein 1; RBQ-1; Retinoblastoma-binding protein 6; p53-associated cellular protein of testis; RBBP6; P2PR, PACT, RBQ1; My038\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant full length Human RBBP6.\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42962800443571,"sku":"BS8619-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42962800476339,"sku":"BS8619-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_4513e786-3400-47b5-b136-d11b72e12f75.jpg?v=1705319015","url":"https:\/\/afsbio.com\/products\/rbbp6-polyclonal-antibody-bs8619","provider":"AFSBio Inc.","version":"1.0","type":"link"}