{"product_id":"rbbp6-rabbit-polyclonal-antibody-es10156","title":"RBBP6 Rabbit Polyclonal Antibody - ES10156","description":"\u003cp\u003eRBBP6 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES10156-50, ES10156-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: approximately 7-10 business days, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],\u003c\/p\u003e \n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human protein . at AA range: 270-350\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: RBBP6,\u003c\/p\u003e \n\n\u003cp\u003eSpecificity: RBBP6 Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e \n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer.\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 197kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. sequence Caution: Contaminating sequence. Potential poly-A sequence. sequence Caution: Intron retention. Similarity: Contains 1 CCHC-type zinc finger. Similarity: Contains 1 DWNN domain. Similarity: Contains 1 RING-type zinc finger. Subcellular Location: Colocalizes with mitotic chromosomes. Subunit: Interacts with p53\/TP53 and RB1. Tissue Specificity: Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer.\u003c\/p\u003e \n\n\u003cp\u003eSubcellular Location: Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Colocalizes with mitotic chromosomes. Colocalizes with NEK6 in the centrosome.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: RBBP6, P2PR, PACT, RBQ1, My038\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: E3 ubiquitin-protein ligase RBBP6, EC 6.3.2.-, Proliferation potential-related protein, Protein P2P-R, Retinoblastoma-binding Q protein 1, RBQ-1, Retinoblastoma-binding protein 6, p53-associated\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 5930\u003c\/p\u003e\n\n\u003cp\u003eHuman SwissProt Number: Q7Z6E9\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P97868\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":45825496350899,"sku":"ES10156-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45825496383667,"sku":"ES10156-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk-biotechnology-logo-product.jpg?v=1786476023","url":"https:\/\/afsbio.com\/products\/rbbp6-rabbit-polyclonal-antibody-es10156","provider":"AFSBio Inc.","version":"1.0","type":"link"}