{"product_id":"rbl2-monoclonal-antibody-bt-mca3127","title":"RBL2 Monoclonal Antibody - BT-MCA3127","description":"\u003cp\u003eRBL2 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA3127-50, BT-MCA3127-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: RBL2 is a Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: RBL2\u003c\/p\u003e\n\n\u003cp\u003eApplications: FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 2C8A8\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: RBL2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human RBL2 (AA: 939-1139) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 128.4kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q08999\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Rb2, P130\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 5934\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238556000435,"sku":"BT-MCA3127-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238556033203,"sku":"BT-MCA3127-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_89b81b0d-4e8a-4bbb-bd38-5fc4b374d100.png?v=1769382525","url":"https:\/\/afsbio.com\/products\/rbl2-monoclonal-antibody-bt-mca3127","provider":"AFSBio Inc.","version":"1.0","type":"link"}