{"product_id":"rbm15-polyclonal-antibody-e-ab-18870","title":"RBM15 Polyclonal Antibody - E-AB-18870","description":"\u003cp\u003eRBM15 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-18870-60, E-AB-18870-120, E-AB-18870-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: RBM15\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: One twenty two protein; One-twenty two protein 1; OTT; OTT1; Putative RNA-binding protein 15; RBM15; RBM15; RNA binding motif protein 15; RNA-binding motif protein 15\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling, Stem Cells\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q96T37\u003c\/p\u003e\n\n\u003cp\u003eBackground: RNA-binding motif protein 15 (RBM15) belongs to the SPEN protein family, which have repressor function in several signaling pathway, and may bind to RNA through interaction with spliceosome components. It was first described as a 5′ translocation partner of the MAL gene in t(1, 22)(p13;q13) infant acute megakaryocytic leukemia, and it functions in murine hematopoiesis through modulating Notch-induced transcriptional activation, which play crucial roles in leukemogenesis. Decreasing RBM15 levels with RNA interference could inhibit the growth and proliferation, block the cell cycle, and induce apoptosis in CML cells.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1.2 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Fusion protein of human RBM15\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:50-1:300, ELISA 1:5000-1:10000\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43130720780467,"sku":"E-AB-18870-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43130720813235,"sku":"E-AB-18870-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43130720846003,"sku":"E-AB-18870-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_0f72b9f7-e07b-4d91-8a4f-19b2f68f34f6.png?v=1709811793","url":"https:\/\/afsbio.com\/products\/rbm15-polyclonal-antibody-e-ab-18870","provider":"AFSBio Inc.","version":"1.0","type":"link"}