{"product_id":"rcc2-polyclonal-antibody-bt-ap07722","title":"RCC2 Polyclonal Antibody - BT-AP07722","description":"\u003cp\u003eRCC2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP07722-20, BT-AP07722-50, BT-AP07722-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: RCC2\/TD-60 is a member of the RCC1 (regulator of chromosome condensation 1) family of guanine nucleotide exchange factors. RCC2\/TD-60 is associated with the chromosome passenger complex (CPC), which also consists of aurora B kinase, borealin, INCENP (inner centromere protein) and survivin. The CPC acts at various stages of mitosis, interacts with microtubules and is required for proper chromosome segregation and cytokinesis. Regulation of aurora B kinase is key in the regulation of the CPC. In late mitosis, RCC2\/TD-60 is required for spindle assembly and recruitment of survivin and aurora B. RCC2\/TD-60 is also required for aurora B activation in vitro and localization of the CPC to centromeres.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: RCC2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: RCC2 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 56085\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9P258; Mouse: Q8BK67\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: RCC2; KIAA1470; TD60; Protein RCC2; RCC1-like protein TD-60; Telophase disk protein of 60 kDa\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 55920; Mouse: 108911\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239875698867,"sku":"BT-AP07722-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239875731635,"sku":"BT-AP07722-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239875764403,"sku":"BT-AP07722-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_9c743269-30e7-4361-806f-5dacb76e058d.png?v=1769400286","url":"https:\/\/afsbio.com\/products\/rcc2-polyclonal-antibody-bt-ap07722","provider":"AFSBio Inc.","version":"1.0","type":"link"}