{"product_id":"recombinant-bax-monoclonal-antibody-e-ab-81433","title":"Recombinant Bax Monoclonal Antibody - E-AB-81433","description":"\u003cp\u003eRecombinant Bax Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-81433-50, E-AB-81433-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Bax\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Apoptosis regulator BAX; BAX; Bax-protein; BAX; BAXA; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; Bcl-2-like protein 4; BCL2 associated X protein; BCL2 associated X protein omega; BCL2 associated X protein transcript variant delta2; Bcl2-L-4; BCL2L4; membrane isoform alpha\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Metabolism\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC-P\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Rabbit Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone No.: R03-1D3\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q07812\u003c\/p\u003e\n\n\u003cp\u003eBackground: BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction . BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria . The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis .\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 300 μg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide of human Bax\u003c\/p\u003e\n\n\u003cp\u003eBuffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity Purified\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:1000 IHC 1:20-1:100\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 21kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 20kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"50μL","offer_id":43149025149107,"sku":"E-AB-81433-50","price":224.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":43149025181875,"sku":"E-AB-81433-100","price":364.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_f3745b4f-b64e-4328-ba87-0016059b1ddc.png?v=1710338540","url":"https:\/\/afsbio.com\/products\/recombinant-bax-monoclonal-antibody-e-ab-81433","provider":"AFSBio Inc.","version":"1.0","type":"link"}