{"product_id":"recombinant-cavia-porcellus-ctla-4-cd152-protein-his-tag-pksq050093","title":"Recombinant Cavia porcellus CTLA-4\/CD152 Protein (His Tag) - PKSQ050093","description":"\u003cp\u003eRecombinant Cavia porcellus CTLA-4\/CD152 Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSQ050093-10, PKSQ050093-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CTLA-4; CD152\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD152; CTLA4\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Cavia porcellus\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: P.Pichia\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: H0VUB1\u003c\/p\u003e\n\n\u003cp\u003eAccession: H0VUB1\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cytotoxic Tlymphocyte 4(CTLA-4, CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Immobilized Mouse B7-1-Fc(Cat: PKSM041366) at 1μg\/ml(100 μl\/well) can bind Cavia porcellus CTLA-4-His. The ED50 of Cavia porcellus CTLA-4-His is 0.17ug\/ml.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ala37-Asp161\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of PBS, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 14.1 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 18-40 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43118130626739,"sku":"PKSQ050093-10","price":368.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43118130659507,"sku":"PKSQ050093-50","price":625.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_b135b63d-9d8b-486b-8b1d-40384c8361c7.png?v=1709636777","url":"https:\/\/afsbio.com\/products\/recombinant-cavia-porcellus-ctla-4-cd152-protein-his-tag-pksq050093","provider":"AFSBio Inc.","version":"1.0","type":"link"}