{"product_id":"recombinant-cynomolgus-il-2rg-cd132-protein-rp01424","title":"Recombinant Cynomolgus IL-2RG\/CD132 Protein - RP01424","description":"\u003cp\u003eRecombinant Cynomolgus IL-2RG\/CD132 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01424-10, RP01424-20, RP01424-50, RP01424-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Cynomolgus IL-2RG\/CD132 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu23-Asn254) of cynomolgus (rhesus macaque) IL-2 R gamma\/CD132 (Accession #NP_001030606.1) fused with a Fc, Avi tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: IL2RG, CD132, CIDX, IMD4, P64, SCIDX, SCIDX1, gammaC, IL2RG\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q38JL2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 641338\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Cynomolgus\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. The common gamma chain (γc) (or IL2RG), is a cytokine receptor subunit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15, and the interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (X-SCID) is a rare and potentially fatal disease caused by mutations of IL2RG, the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor based on chemical cross-linking data, the ability of IL2RG to augment IL-4 binding affinity. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why a deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-hFc\u0026amp;Avi\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: LNTTILTPNGNEDATTDFFLTSMPTDSLSVSTLPLPEVQCFVFNVEYMNCTWNSSSEPQPTNLTLHYWYKNSDNDKVQKCSHYLFSEEITSGCQLQEKEIHLYQTFVVQLQDPREPRRQATQMLKLQNLVIPWAPENLTLRKLSESQLELNWNNRFLNHCLEHLVQYRTDWDHSWTEQSVDYRHKFSLPSVDGQKRYTFRVRSRFNPLCGSAQHWSEWSHPIHWGSNSSKEN\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198249033907,"sku":"RP01424-10","price":182.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198249066675,"sku":"RP01424-20","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198249099443,"sku":"RP01424-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198249132211,"sku":"RP01424-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_a2785f06-c1fd-4294-bfe1-ddffc607a312.png?v=1766959712","url":"https:\/\/afsbio.com\/products\/recombinant-cynomolgus-il-2rg-cd132-protein-rp01424","provider":"AFSBio Inc.","version":"1.0","type":"link"}