{"product_id":"recombinant-cynomolgus-interleukin-4-receptor-subunit-alpha-il-4-rα-protein-his-tag-pksq050053","title":"Recombinant Cynomolgus Interleukin-4 Receptor Subunit Alpha\/IL-4 Rα Protein (His Tag) - PKSQ050053","description":"\u003cp\u003eRecombinant Cynomolgus Interleukin-4 Receptor Subunit Alpha\/IL-4 Rα Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSQ050053-10, PKSQ050053-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: IL-4RA\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Interleukin-4 receptor subunit alpha; IL-4R-alpha; CD124; IL4-BP; Soluble IL-4R-alpha\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Cynomolgus macaques\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: G7Q0S7\u003c\/p\u003e\n\n\u003cp\u003eAccession: G7Q0S7\u003c\/p\u003e\n\n\u003cp\u003eBackground: Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions as receptor for both interleukin 4 and interleukin 13 and couples to the JAK1\/2\/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4\/IL13 responses are involved in regulating IgE production and chemokine and mucus production at sites of allergic inflammation. In certain cell types, IL-4RA can signal through activation of insulin receptor substrates, IRS1\/IRS2. The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequently it recruits to the complex of the common gamma chain. In immune cells, IL-4RA creates a type I receptor. In non-immune cells, it forms a type II receptor with of IL13RA1. IL4R can also interact with the IL13\/IL13RA1 complex to form a similar type II receptor and interacts with the SH2-containing phosphatases, PTPN6\/SHIP1, PTPN11\/SHIP2 and INPP5D\/SHIP.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Immobilized Human IL-4(Cat: PKSH033456) at 10μg\/ml(100 μl\/well) can bind Human IL-4Ra-His. The ED50 of Human IL-4Ra-His is 7μg\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met26-Arg232\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 24.6 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 40 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43118130495667,"sku":"PKSQ050053-10","price":180.6,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43118130528435,"sku":"PKSQ050053-50","price":525.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_f3fb5da1-ac2f-49d2-bf3f-892350d1ef2d.png?v=1709636771","url":"https:\/\/afsbio.com\/products\/recombinant-cynomolgus-interleukin-4-receptor-subunit-alpha-il-4-r%ce%b1-protein-his-tag-pksq050053","provider":"AFSBio Inc.","version":"1.0","type":"link"}