{"product_id":"recombinant-cynomolgus-tpbg-5t4-c-6his-pksq050103","title":"Recombinant Cynomolgus TPBG\/5T4 (C-6His) - PKSQ050103","description":"\u003cp\u003eRecombinant Cynomolgus TPBG\/5T4 (C-6His)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSQ050103-10, PKSQ050103-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: TPBG; 5T4\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: 5T4 Protein; Human; 5T4AG Protein; Human; M6P1 Protein; Human; WAIF1 Protein; Human\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q4R8Y9\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Cynomolgus macaques\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q4R8Y9\u003c\/p\u003e\n\n\u003cp\u003eBackground: Trophoblast glycoprotein, also known as TPBG and 5T4, it belongs to the LRR family of proteins. The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway. TPBG may function as an inhibitor of Wnt\/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. It expressed by all types of trophoblasts as early as 9 weeks of development. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Thr35-Ser355\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 35.7 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 55-80 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43072232554675,"sku":"PKSQ050103-10","price":275.8,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43072232587443,"sku":"PKSQ050103-50","price":824.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_0875596d-0a26-4a35-a9a7-e492febdc502.png?v=1708684812","url":"https:\/\/afsbio.com\/products\/recombinant-cynomolgus-tpbg-5t4-c-6his-pksq050103","provider":"AFSBio Inc.","version":"1.0","type":"link"}