{"product_id":"recombinant-egfr-monoclonal-antibody-e-ab-81439","title":"Recombinant EGFR Monoclonal Antibody - E-AB-81439","description":"\u003cp\u003eRecombinant EGFR Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-81439-50, E-AB-81439-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: EGFR\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Cell growth inhibiting protein 40; Cell proliferation inducing protein 61; EGF R; EGFR; Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog); Epidermal growth factor receptor; erb-b2 receptor tyrosine kinase 1; ERBB; ERBB1; Errp; HER1; mENA; \u003cbr\u003e\nNISBD2; SA7; wa2; Wa5\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IF\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Rabbit Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone No.: R03-6B1\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P00533\u003c\/p\u003e\n\n\u003cp\u003eBackground: EGFR, also named as ERBB1, is a cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. The gene resides on chromosome 7p12, encoding a 170 kDa membrane-associated glycoprotein. Recent studies have shown EGFR plays a critical role in cancer development and progression, including cell proliferation, apoptosis, angiogenesis, and metastatic spread. Mutations in this gene are associated with lung cancer.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 300 μg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide of human EGFR\u003c\/p\u003e\n\n\u003cp\u003eBuffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity Purified\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:1000-1:2000 IF 1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 134kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 175kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"50μL","offer_id":43149025575091,"sku":"E-AB-81439-50","price":224.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":43149025607859,"sku":"E-AB-81439-100","price":364.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_46f3238c-10e7-4bbb-b318-1de3cc913de5.png?v=1710338557","url":"https:\/\/afsbio.com\/products\/recombinant-egfr-monoclonal-antibody-e-ab-81439","provider":"AFSBio Inc.","version":"1.0","type":"link"}