{"product_id":"recombinant-fasr-human-bk0303","title":"Recombinant FasR, Human - BK0303","description":"\u003cp\u003eRecombinant FasR, Human\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BK0303-10, BK0303-50\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK 293\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: 17~29 kDa, observed by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95% as analyzed by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eBiological Activity: ED50 \u0026lt;0.4 μg\/ml, measured by its ability to inhibit the cytotoxicity of Jurkat cells in the presence of 20ng\/ml of human Fas Ligand.\u003c\/p\u003e\n\n\u003cp\u003ePhysical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized after extensive dialysis against PBS.\u003c\/p\u003e\n\n\u003cp\u003eAA Sequence: QVTDINSKGLELRKt VTt VETQNLEGLHHDGQFCHKPCPPGERKARDCt VNGDEPDCVPCQEGKEYTDKAHFSSKCRRCR\u003cbr\u003e\n LCDEGHGLEVEINCTRTQNTKCRCKPNFFCNSt VCEHCDPCTKCEHGIIKECTLTSNTKCKEEGSRS\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.2 EU\/μg, determined by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Reconstituted in ddH2O or PBS at 100 μg\/ml.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Lyophilized recombinant Human Fas Receptor remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Human Fas Receptor should be stable up to 1 week at 4°C or up to 2 months at -20°C.\u003c\/p\u003e\n\n\u003cp\u003eUsage: This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Fas Receptor and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL.\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"10μg","offer_id":42882261713075,"sku":"BK0303-10","price":256.94,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":42882261745843,"sku":"BK0303-50","price":813.32,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_bb0b7ee5-b1cc-4f91-8730-c38157810fe3.jpg?v=1702050267","url":"https:\/\/afsbio.com\/products\/recombinant-fasr-human-bk0303","provider":"AFSBio Inc.","version":"1.0","type":"link"}